Many, if not most, instances of fraud use at least some spoofing. Think of spoofing as little lies. Spoofing intends to show you one thing, while giving you another.
For example, spoofing can take the form of web links in email. What is displayed (your bank's website) can actually be another thing (the scammer's website). This is also done with phone calls. Caller ID information should tell you who is calling, but scammers can change this information to look "real".
You should be aware that technology can be used to cause spoofing, and the result could be fraud. See the article in the Security Center about Phishing to learn more about what can happen and how you can protect yourself.